Top 10 Facts To Know About Palmitoylethanolamide Supplement

Top 10 Facts To Know About Palmitoylethanolamide Supplement

Palmitoylethanolamide (PEA), a fatty acid that is manufactured by the body, is beneficial in the treatment of inflammation and pain. The endogenous agent can be found in the case of milk and egg. PEA has been used for many decades in Europe and the Netherlands, but since the 1990s, it has gained popularity in the U.S. also. It is mainly classified as “food for medical purposes” in  Europe. It is also used as a diet supplement in the USA. In this article, some interesting facts about palmitoylethanolamide supplements will be discussed.

Facts to know about palmitoylethanolamide supplement

PEA (palmitoylethanolamide) has shown effectiveness for chronic pain of several types, such as inflammatory pain, neuropathic (nerve) pain, visceral pain such as interstitial cystitis and endometriosis, Muscle recovery and muscle pain, and immune system support. PEA supports the healthy function of cells found in the body’s immune and nervous systems.PEA is available as a supplement in the form of capsules, tablets, and powder forms. In Spain and Italy, PEA is marketed as food for particular medical purposes.

Most of the PEA supplements that are available to consumers are of synthetic origin. Hence, they do not come under the category of “natural supplements. PEA is not a water-soluble product, and also the rate at which it dissolves in the stomach and intestine is also slow for oral absorption and bioavailability. PEA is metabolized and synthesized by different animal cell types, and these are also present in plants.

Generally, PEA has been advised to be taken between 300-600 mg twice a day or maybe up to 1200 mg/day. According to most researchers, one can take this treatment for up to 3-6 months. One can get relief from some of the health issues like arthritis, peripheral neuropathies, sciatic pain, dental pain, chronic pelvic pain, neuropathic pain – related to stroke & multiple sclerosis, vaginal pain, different lower back pain such as failed back surgery syndrome, herniated disc disease. Some of the other benefits of PEA are listed below:

  • This may be helpful for stroke and neurodegenerative diseases because it seems to help the brain cells survive and cause lower inflammation.
  • PEA also protects the nerve cells in the eyes, which are very crucial for maintaining proper vision.
  • This palmitoylethanolamide supplement is also helpful in treating some symptoms of depression.
  • This supplement can reduce the adverse effects and pain and thus improve the quality of life and also cognition.


Palmitoylethanolamide, which is otherwise known as PEA, is naturally produced in the body to reduce pain and inflammation. The highest amounts of PEA can be found in soybeans, soy lecithin, egg yolk, alfalfa, and peanuts. Some, more research is required to determine PEA’s exact nature and the long-term safety of Pyrroloquinoline Quinone. This can also be used as a remedy for influenza and the common cold. The doses should be kept minimal in the starting to avoid any significant side effects. Also, it should not be used for a longer period.

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